Reactome Content Service API

The Reactome Content Service provides programmatic access to all knowledgebase content including pathways, reactions, physical entities, complexes, and molecular interactions. It supports querying by identifier, retrieving pathway hierarchies, exporting pathway diagrams in multiple formats (PNG, JPG, SVG, PDF, SBML, SBGN), searching via Solr full-text search, querying PSICQUIC interactor databases, and mapping external identifiers to Reactome entities. The API covers human biology as well as orthologous reactions for over 14 species. No authentication is required and the API is free to use for research purposes.