Reactome Analysis Service API

The Reactome Analysis Service enables pathway enrichment analysis for lists of gene or protein identifiers. Users can submit identifier lists via direct POST, file upload, or URL reference. The service automatically detects overrepresentation analysis for identifier lists or expression analysis for tab-separated values with numeric expression data. Results include pathway hit data, p-values, false discovery rate (FDR), and entity and reaction counts. Analysis results are assigned a token valid for 7 days, allowing subsequent retrieval, filtering by species, pagination, and PDF report generation without resubmitting data. Species comparison against Homo sapiens is also supported.